The power of GYM exercise
There is a correlation between breast cancer disease status and immune cell levels. Specifically, factors such as breast cancer grade, lymph node involvement, and hormone receptor status affect exercise-induced immune cell mobilization.
For example, breast cancer grade was inversely associated with CD4+ cell count at baseline; lymph node involvement was associated with total white blood cell count, CD3+ T-cell count, CD4+ T-cell count, CD19+ B-cell count, and CD14+ CD16+ monocyte count There was a negative correlation at baseline; hormone receptor status was also negatively or positively correlated with counts of different types of immune cells at baseline. Therefore, it is very necessary for breast cancer patients to increase immune cell levels.
Recently, a study published in Scientific Reports, a subsidiary of Nature, explored the impact of acute exercise on circulating immune cells in newly diagnosed breast cancer patients. The study found that acute exercise can promote the mobilization and increase of immune cells, which may have an impact on the immune function of breast cancer patients. Have a positive impact.
The overall research design was relatively simple. 20 female breast cancer patients who had not received any cancer treatment were tested for changes in immune cell levels in blood samples immediately after 10 minutes of moderate to low-intensity spinning cycling and 30 minutes later.
The study found that counts of total white blood cells (CD45+), CD19+ B cells, total NK cells, CD56+ CD16+ NK cells, and CD14+ CD16+ monocytes increased after acute exercise. In addition, the ratio of total NK cells and CD56+ CD16+ NK cells to total leukocytes and the ratio of CD14+ CD16+ monocytes to total monocytes increased. After 30 minutes of exercise, the levels of the above-mentioned cells decreased. Except for total white blood cells (CD45+) which were still higher than the baseline level (p<0.05), the rest returned to the baseline level.
For T cell statistics, it was found that the changes in the number of total T cells and helper T cells were not significant, and the number of CD8+ cytotoxic T cells increased significantly immediately after exercise (p < 0.05) and returned to baseline levels 30 minutes after exercise. There was no significant change in the number of CD4 + CD8 + double positive or CD4-CD8- double negative T cells.
Regarding the number of granulocytes and monocytes, it was found that the number of granulocytes and total monocytes did not change significantly, but the number of CD14+CD16+ monocytes increased immediately after exercise (p<0.05), and was significantly higher than the level before exercise. 30 minutes after baseline (p<0.05). The numbers of classical CD14+CD16− and nonclassical CD14−CD16+ monocytes did not change significantly.
Summarize
Acute exercise causes changes in the number of immune cells in the blood of newly diagnosed breast cancer patients. After acute exercise, the number of total white blood cells, T cells, B cells, NK cells, and monocytes increased, while the number of granulocytes and classic The number of monocytes did not change.
Furthermore, acute exercise also resulted in increased proportions of total NK cells and CD56+CD16+ NK cells, as well as increased proportions of CD8+ T cells and CD14+CD16+ monocytes.
These results indicate that acute exercise can promote the mobilization and increase of immune cells. This research result has implications for the rehabilitation treatment of breast cancer patients, that is, appropriate exercise can enhance the patient’s immune system function and help improve treatment effects and survival rates. .
Written by: JOYEN
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